Metformin Causing Vitamin B12 Deficiency: A Guilty Verdict Without Sufficient Evidence
نویسندگان
چکیده
منابع مشابه
Metformin causing vitamin B12 deficiency: a guilty verdict without sufficient evidence.
Metformin causing vitamin B12 (B12) deficiency has become a traditional myth in medical literature (1,2). But what evidence do we have? The possibility to measure holotranscobalamin (active B12) and the metabolic marker, methylmalonic acid (MMA), has changed the practice of diagnosing B12 deficiency in recent years. We have learned that not all low plasma B12 means a “deficiency” and not all hi...
متن کاملMetformin-related vitamin B12 deficiency.
Metformin is an invaluable hypoglycaemic agent. We report two cases who had symptomatic vitamin B12 deficiency related to metformin use; the mechanisms are discussed. The clinician must be aware of the possibility of metformin-associated B12 deficiency in users who suffer cognitive impairment, peripheral neuropathy, subacute combined degeneration of the cord or anaemia.
متن کاملMetformin associated B12 deficiency.
According to the ADA guidelines, metformin and lifestyle modifications are the first line therapies in the treatment of type 2 diabetes mellitus. Metformin does, however, cause vitamin B-12 malabsorption, which may increase the risk of developing vitamin B-12 deficiency--a clinically important and treatable condition. Here we report a case of 60 year old diabetic male presenting with clinical f...
متن کاملMetformin-associated vitamin B12 deficiency in the elderly
Objective. To compare the prevalence of the vitamin B12 deficiency in geriatric diabetic patients treated with or without metformin. Methods. Records of 134 patients with diabetes mellitus (DM) aged 61 to 93 (mean, 80) years who were treated with (n=56) or without (n=78) metformin were reviewed. Patient demographics (age, gender, duration of DM, smoking status, alcohol consumption), medication ...
متن کاملMetformin and Vitamin B12 Deficiency: Where Do We Stand?
The association between metformin use and low vitamin B12 levels in type 2 diabetes mellitus patients is well-established. However, many aspects of the topic remain to be elucidated. There is still controversy on the current diagnostic approaches to vitamin B12 deficiency. It is now believed that measuring the serum levels of the vitamin may not reflect its metabolic status. Moreover, there wer...
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ژورنال
عنوان ژورنال: Diabetes Care
سال: 2014
ISSN: 0149-5992,1935-5548
DOI: 10.2337/dc13-2278